There have been clashes between Palestinians and Israeli police outside the Al-Aqsa mosque in Jerusalem, ahead of a planned Jewish nationalist march.
More than 300 people were injured, as crowds threw stones and officers fired stun grenades and rubber bullets.
It comes amid soaring tensions in the city, which has seen weeks of unrest.
Earlier, Israeli police decided to bar Jews from visiting the compound where the mosque is located during the annual Jerusalem Day Flag March.
The event marks Israel’s capture of East Jerusalem – home to the Old City and its holy sites – in 1967, and usually sees hundreds of flag-waving Israeli youth make their way through Muslim areas via Damascus Gate, chanting and singing patriotic songs.
It is regarded by many Palestinians as a deliberate provocation. This year’s march is also taking place in the final days of the Islamic holy month of Ramadan.
The al-Aqsa mosque, the third holiest site in Islam, is located on a hilltop complex known by Muslims as the Haram al-Sharif (Noble Sanctuary) and by Jews as the Temple Mount. Jews revere it as the location of two Biblical Temples and it is the holiest site in Judaism.
The latest violence follows days of clashes between Palestinians and Israeli police in the nearby Sheikh Jarrah district of East Jerusalem, with the possible eviction of Palestinian families from their homes there by Jewish settlers a focal point for Palestinian anger.
Israel’s Supreme Court had been due to hold a hearing in the long-running case on Monday, but the session was postponed due to the unrest.
Israel’s police force said thousands of Palestinians barricaded themselves in the building overnight with stones and Molotov cocktails in anticipation of a confrontation during the Jerusalem Day Flag March, which was scheduled to start at about 16:00 (13:00 GMT).
Officers were ordered to enter the mosque compound to “repel the rioters using demonstration dispersal methods” on Monday morning after a police post was attacked and stones were thrown towards a nearby road, it added.
For over an hour, police fired stun grenades, rubber bullets and tear gas at Palestinians, who threw stones and other objects.
Video posted on social media showed crowds running for cover and some of the stun-grenade canisters landing inside the mosque.
During clashes outside the Old City walls, a car was pelted with stones before crashing into bollards and hitting a man.
The Palestinian Red Crescent said 305 Palestinians were injured in the clashes, and that 228 were taken to hospital for treatment. Seven of them are in a critical condition.
The Israeli police force said 21 officers were injured and that three required hospital treatment.
Israel’s Prime Minister, Benjamin Netanyahu, defended the police.
“This is a battle between tolerance and intolerance, between lawless violence and order,” he said. “Elements that want to expropriate our rights periodically force us to stand strong, like Israel’s police officers are doing.”